Molecular Circuits of Resolution in Renal Disease

被引：23

作者：

Boergeson, Emma ^{[1
]}

Godson, Catherine ^{[1
]}

机构：

[1] Univ Coll Dublin, Sch Med & Med Sci, UCD Conway Inst, UCD Diabet Res Ctr, Dublin, Ireland

来源：

THESCIENTIFICWORLDJOURNAL | 2010年 / 10卷

基金：

爱尔兰科学基金会;

关键词：

lipxoins; resolvins; protectins; renal inflammation; ASPIRIN-TRIGGERED LIPOXIN; NF-KAPPA-B; A(4) STABLE ANALOGS; GROWTH-FACTOR-BETA; DOCOSAHEXAENOIC ACID; 15-EPI-LIPOXIN A(4); GENE-EXPRESSION; TGF-BETA; DENDRITIC CELLS; CUTTING EDGE;

D O I：

10.1100/tsw.2010.120

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Inflammation is a common feature of renal pathology. Lipid mediators, such as lipoxins, resolvins, and protectins, can actively promote the resolution of inflammation by inhibiting polymorphonuclear cell infiltration to the site of inflammation, shifting the cytokine milieu from proinflammatory to proresolving and increasing the nonphlogistic phagocytosis of apoptotic cells by macrophages. Here we review the evidence for molecular circuits of resolution in renal disease.

引用

页码：1370 / 1385

页数：16

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