Arterial Spin Labeling Blood Flow MRI: Its Role in the Early Characterization of Alzheimer's Disease

被引：169

作者：

Alsop, David C. ^{[1
,2
]}

Dai, Weiying ^{[1
,2
]}

Grossman, Murray ^{[3
]}

Detre, John A. ^{[3
,4
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA

[4] Univ Penn, Med Ctr, Dept Radiol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 20卷 / 03期

关键词：

Cerebral blood flow; diagnosis; imaging; magnetic resonance imaging; perfusion; MILD COGNITIVE IMPAIRMENT; CASL-PERFUSION MRI; TRANSIT-TIME; CEREBRAL HYPOPERFUSION; GLUCOSE-METABOLISM; CSF BIOMARKERS; HUMAN BRAIN; INVERSION; FMRI; CBF;

D O I：

10.3233/JAD-2010-091699

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Arterial spin labeling (ASL) enables the noninvasive, quantitative imaging of cerebral blood flow using standard magnetic resonance imaging (MRI) equipment. Because it requires no contrast injection, ASL can add resting functional information to MRI studies measuring atrophy and signs of ischemic injury. Key features of ASL technology that may affect studies in Alzheimer's disease are described. The existing literature describing ASL blood flow imaging applied to Alzheimer's disease and related dementia is reviewed, and the potential role of ASL in treatment and prevention studies of early Alzheimer's disease is discussed.

引用

页码：871 / 880

页数：10

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