The gut microbiota and host health: a new clinical frontier

被引：2049

作者：

Marchesi, Julian R. ^{[3
,4
]}

Adams, David H. ^{[5
]}

Fava, Francesca ^{[6
]}

Hermes, Gerben D. A. ^{[7
,8
]}

Hirschfield, Gideon M. ^{[5
]}

Hold, Georgina ^{[9
]}

Quraishi, Mohammed Nabil ^{[5
]}

Kinross, James ^{[10
]}

Smidt, Hauke ^{[7
]}

Tuohy, Kieran M. ^{[6
]}

Thomas, Linda V. ^{[11
]}

Zoetendal, Erwin G. ^{[7
,8
]}

Hart, Ailsa ^{[1
,2
]}

机构：

[1] St Marks Hosp, IBD Unit, Watford Rd, London HA13UJ, England

[2] Univ London Imperial Coll Sci Technol & Med, Watford Rd, London HA13UJ, England

[3] Cardiff Univ, Sch Biosci, Museum Ave, Cardiff, Wales

[4] Univ London Imperial Coll Sci Technol & Med, Ctr Digest & Gut Hlth, London, England

[5] Univ Birmingham, Liver Res Ctr, NIHR Biomed Res Unit, Birmingham, W Midlands, England

[6] Res & Innovat Ctr, Nutr & Nutrigen Grp, Dept Food Qual & Nutr, Trento, Italy

[7] Wageningen Univ, Microbiol Lab, NL-6700 AP Wageningen, Netherlands

[8] TIFN, Wageningen, Netherlands

[9] Univ Aberdeen, Sch Med & Dent, Div Appl Med, Inst Med Sci, Aberdeen, Scotland

[10] Univ London Imperial Coll Sci Technol & Med, Fac Med, Sect Computat & Syst Med, London, England

[11] Yakult UK Ltd, Middlesex, England

来源：

GUT | 2016年 / 65卷 / 02期

关键词：

INFLAMMATORY-BOWEL-DISEASE; MUCOSA-ASSOCIATED MICROBIOTA; HUMAN COLONIC MICROBIOTA; FATTY LIVER-DISEASE; ULCERATIVE-COLITIS; COLORECTAL-CANCER; FECAL MICROBIOTA; INTESTINAL MICROBIOTA; ESCHERICHIA-COLI; CROHNS-DISEASE;

D O I：

10.1136/gutjnl-2015-309990

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Over the last 10-15 years, our understanding of the composition and functions of the human gut microbiota has increased exponentially. To a large extent, this has been due to new 'omic' technologies that have facilitated large-scale analysis of the genetic and metabolic profile of this microbial community, revealing it to be comparable in influence to a new organ in the body and offering the possibility of a new route for therapeutic intervention. Moreover, it might be more accurate to think of it like an immune system: a collection of cells that work in unison with the host and that can promote health but sometimes initiate disease. This review gives an update on the current knowledge in the area of gut disorders, in particular metabolic syndrome and obesity-related disease, liver disease, IBD and colorectal cancer. The potential of manipulating the gut microbiota in these disorders is assessed, with an examination of the latest and most relevant evidence relating to antibiotics, probiotics, prebiotics, polyphenols and faecal microbiota transplantation.

引用

页码：330 / 339

页数：10

共 111 条

[1]

Immunology of the gut and liver: a love/hate relationship [J].