Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats

被引：83

作者：

Bhattacharya, Sanchari ^{[1
]}

Mondal, Laboni ^{[1
]}

Mukherjee, Biswajit ^{[1
]}

Dutta, Lopamudra ^{[1
]}

Ehsan, Iman ^{[1
]}

Debnath, Mita C. ^{[2
]}

Gaonkar, Raghuvir H. ^{[2
]}

Pal, Murari M. ^{[1
]}

Majumdar, Subrata ^{[3
]}

机构：

[1] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata 700032, W Bengal, India

[2] Indian Inst Chem Biol, CSIR, Infect Dis & Immunol Div, Kolkata, W Bengal, India

[3] Bose Inst, Div Mol Med, Kolkata, W Bengal, India

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2018年 / 14卷 / 06期

关键词：

Apigenin nanoparticles; Hepatocellular carcinoma; Pharmacokinetics; Gamma scintigraphy; Histopathology; LC-MS/MS; EXPRESSION; APOPTOSIS; LIVER;

D O I：

10.1016/j.nano.2018.05.011

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Hepatocellular carcinoma (HCC) is one of the major causes of cancer related death globally. Apigenin, a dietary flavonoid, possesses antitumor activity against HCC cells in-vitro. Development, physicochemical characterization of apigenin loaded nanoparticles (ApNp), biodistribution pattern and pharmacokinetic parameters of apigenin upon intravenous administration of ApNp, and effect of ApNp treatment in rats with HCC were investigated. Apigenin loaded nanoparticles had a sustained drug release pattern and successfully reached the hepatic cancer cells in-vitro as well as in liver of carcinogenic animals. ApNp predominantly delayed the progress of !ICC in chemical induced hepatocarcinogenesis in rats. Quantification of apigenin by liquid chromatography-mass spectroscopy (LC-MS/MS) showed that apigenin availability significantly increased in blood and liver upon ApNp treatment. Apigenin loaded nanoparticle delivery substantially controlled the severity of hepatocellular carcinoma and could be a future hope for lingering the survival in hepatic cancer patients. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：1905 / 1917

页数：13

共 50 条

[1]

Release Kinetics Study of Poorly Water-Soluble Drugs from Nanoparticles: Are We Doing It Right? [J].

Abouelmagd, Sara A. ;

Sun, Bo ;

Chang, Alice C. ;

Ku, Youn Jin ;

Yeo, Yoon .

MOLECULAR PHARMACEUTICS, 2015, 12 (03) :997-1003

[2]

The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes [J].

Ahn, D ;

Putt, D ;

Kresty, L ;

Stoner, GD ;

Fromm, D ;

Hollenberg, PF .

CARCINOGENESIS, 1996, 17 (04) :821-828

[3]

Colloidal gold-loaded, biodegradable, polymer-based stavudine nanoparticle uptake by macrophages: an in vitro study [J].

Basu, Sumit ;

Mukherjee, Biswajit ;

Chowdhury, Samrat Roy ;

Paul, Paramita ;

Choudhury, Rupak ;

Kumar, Ajeet ;

Mondal, Laboni ;

Hossain, Chowdhury Mobaswar ;

Maji, Ruma .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :6049-6061

[4]

Principles of nanoparticle design for overcoming biological barriers to drug delivery [J].

Blanco, Elvin ;

Shen, Haifa ;

Ferrari, Mauro .

NATURE BIOTECHNOLOGY, 2015, 33 (09) :941-951

[5]

Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns [J].

Cai, Jing ;

Zhao, Xiang-Li ;

Liu, An-Wen ;

Nian, Hua ;

Zhang, Shu-Hui .

PHYTOMEDICINE, 2011, 18 (05) :366-373

[6]

Binding Citrus flavanones to human serum albumin: effect of structure on affinity [J].

Cao, Hui ;

Chen, Longsheng ;

Xiao, Jianbo .

MOLECULAR BIOLOGY REPORTS, 2011, 38 (04) :2257-2262

[7]

Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells [J].

Chiang, Lien-Chai ;

Ng, Lean Teik ;

Lin, I. -Cheng ;

Kuo, Po-Lin ;

Lin, Chun-Ching .

CANCER LETTERS, 2006, 237 (02) :207-214

[8]

Review of Natural Compounds for Potential Skin Cancer Treatment [J].

Chinembiri, Tawona N. ;

du Plessis, Lissinda H. ;

Gerber, Minja ;

Hamman, Josias H. ;

du Plessis, Jeanetta .

MOLECULES, 2014, 19 (08) :11679-11721

[9]

Pulmonary Delivery of Voriconazole Loaded Nanoparticles Providing a Prolonged Drug Level in Lungs: A Promise for Treating Fungal Infection [J].

Das, Pranab Jyoti ;

Paul, Paramita ;

Mukherjee, Biswajit ;

Mazumder, Bhaskar ;

Mondal, Laboni ;

Baishya, Rinku ;

Debnath, Mita Chatterjee ;

Dey, Kumar Saurav .

MOLECULAR PHARMACEUTICS, 2015, 12 (08) :2651-2664

[10]

Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro [J].

Das, Sreemanti ;

Das, Jayeeta ;

Samadder, Asmita ;

Paul, Avijit ;

Khuda-Bukhsh, Anisur Rahman .

TOXICOLOGY LETTERS, 2013, 223 (02) :124-138

← 1 2 3 4 5 →