Mapping cortical change across the human life span

被引:1678
作者
Sowell, ER
Peterson, BS
Thompson, PM
Welcome, SE
Henkenius, AL
Toga, AW
机构
[1] Univ Calif Los Angeles, Lab Neuro Imaging, Dept Neurol, Los Angeles, CA 90095 USA
[2] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA
[3] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
关键词
D O I
10.1038/nn1008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We used magnetic resonance imaging and cortical matching algorithms to map gray matter density (GMD) in 176 normal individuals ranging in age from 7 to 87 years. We found a significant, nonlinear decline in GMD with age, which was most rapid between 7 and about 60 years, over dorsal frontal and parietal association cortices on both the lateral and interhemispheric surfaces. Age effects were inverted in the left posterior temporal region, where GMD gain continued up to age 30 and then rapidly declined. The trajectory of maturational and aging effects varied considerably over the cortex. Visual, auditory and limbic cortices, which are known to myelinate early, showed a more linear pattern of aging than the frontal and parietal neocortices, which continue myelination into adulthood. Our findings also indicate that the posterior temporal cortices, primarily in the left hemisphere, which typically support language functions, have a more protracted course of maturation than any other cortical region.
引用
收藏
页码:309 / 315
页数:7
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