Gastric emptying and motility: Assessment with MR imaging - Preliminary observations

PURPOSE: To evaluate a magnetic resonance (MP) imaging method for simultaneous assessment of gastric emptying and motility. MATERIALS AND METHODS: Gastric emptying and motility Were measured in. nine volunteers after ingestion of a liquid meal. A specially designed MR imaging protocol was used that allowed simultaneous assessment of gastric emptying (spatial resolution, 1.5 mm; corrected for gastric secretion volume) and gastric motility (temporal resolution, 1:2 seconds, spatial resolution 3.1 mm). To evaluate the ability to detect small changes in gastric motor activity with findings from this method, the influence of-a prokinetic agent (loxiglumide) on gastric emptying and motility was tested in five volunteers. RESULTS: Each contraction could be individually visualized at MR imaging. Administration of loxiglumide resulted in decreased gastric half-emptying time (mean +/- 1 standard error of the mean, 88.1 minutes +/- 6.3 for the placebo and 39.1 minutes +/- 6.7 for loxiglumide) and increased gastric motility (contraction frequency, 2.26 contractions:per minute +/- 0.15-for the placebo and 3.04 per minute +/- 0.04 for loxiglumide). CONCLUSION: MR imaging: makes it feasible to study gastric emptying and gastric motility and to determine the influence of drugs on gastric motor activity.