Productive RUPture: activation of transcription factors by proteasomal processing

被引：50

作者：

Rape, M ^{[1
]}

Jentsch, S ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1695卷 / 1-3期

关键词：

RUP; processing; CDC48; NF-kappa B; SPT23; MGA2; ER membrane; OLE pathway;

D O I：

10.1016/j.bbamcr.2004.09.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteasomes usually degrade proteins completely into small peptides. In a few cases. however. proteasomal degradation rather results in protein processing, thereby yielding proteins of different biological activity. This process. termed "regulated ubiquitin/proteasome-dependent processing" or RUP, is essential for the function of certain transcription factors and crucial for their regulation. Examples are proteins of the mammalian NF-kappaB family and the yeast proteins SPT23 and MGA2. In this review. we summarize the available data and suggest a mechanistic model for proteasomal processing, (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：209 / 213

页数：5

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