Molecular studies of identification of genes for osteoporosis: the 2002 update

被引:169
作者
Liu, YZ
Liu, YJ
Recker, RR
Deng, HW [2 ]
机构
[1] Creighton Univ, Osteoporosis Res Ctr, Omaha, NE 68131 USA
[2] Creighton Univ, Dept Biomed Sci, Omaha, NE 68131 USA
[3] Hunan Normal Univ, Coll Life Sci, Lab Mol & Stat Genet, Changsha 410081, Hunan, Peoples R China
关键词
D O I
10.1677/joe.0.1770147
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We aim to give a comprehensive review, updated to 2002, of the most important and representative molecular genetic studies, performed mainly within the past decade, that aimed to identify the gene(s) involved in osteoporosis. Early reviews were largely confined to association studies in humans, but we review here, separately, the results of both association and linkage studies in humans, and quantitative trait locus (QTL) mapping in animal models. The main results of all the studies are tabulated for comparison and ease of reference, and to provide a comprehensive retrospective view of molecular genetics studies of osteoporosis. The most striking findings and the most representative studies are singled out for comment regarding the immediacy of their influence on present understanding of the genetics of osteoporosis and on the current status of genetic research in osteoporosis. This is particularly relevant for studies on the association of the vitamin D receptor (VDR) gene, for which there has been a large body of studies and reviews published. The format adopted by this review should be ideal for accommodating future new advances and studies in a fairly young field that is still developing rapidly.
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收藏
页码:147 / 196
页数:50
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