Long-term depression in the CNS

被引：703

作者：

Collingridge, Graham L. ^{[1
,2
,3
]}

Peineau, Stephane ^{[1
,4
,5
,6
]}

Howland, John G. ^{[7
,8
]}

Wang, Yu Tian ^{[9
,10
,11
]}

机构：

[1] Univ Walk, Sch Med Sci, Dept Anat, MRC Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

[2] Univ British Columbia, Dept Psychiat, Brain Res Ctr, Vancouver, BC V6T 1Z3, Canada

[3] Seoul Natl Univ, Dept Brain & Cognit Sci, Seoul 151747, South Korea

[4] Hop Robert Debre, INSERM, U676, F-75019 Paris, France

[5] Univ Paris 07, Fac Med Denis Diderot, Paris, France

[6] PremUP, Paris, France

[7] Univ Saskatchewan, Dept Psychol, Neural Syst & Plast Res Grp, Saskatoon, SK S7N 5A5, Canada

[8] Univ Saskatchewan, Dept Physiol, Neural Syst & Plast Res Grp, Saskatoon, SK S7N 5A5, Canada

[9] Univ British Columbia, Dept Med, Coastal Hlth Res Inst, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada

[10] China Med Univ Hosp, Ctr Neuropsychiat, Taichung, Taiwan

[11] China Med Univ Hosp, Grad Inst Immunol, Taichung, Taiwan

来源：

NATURE REVIEWS NEUROSCIENCE | 2010年 / 11卷 / 07期

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

BIDIRECTIONAL SYNAPTIC PLASTICITY; METABOTROPIC GLUTAMATE RECEPTORS; NR2B-CONTAINING NMDA RECEPTORS; ACTIVATED PROTEIN-KINASE; FRAGILE-X-SYNDROME; AMPA-RECEPTOR; CA1; REGION; NUCLEUS-ACCUMBENS; TYROSINE PHOSPHORYLATION; BEHAVIORAL SENSITIZATION;

D O I：

10.1038/nrn2867

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various pathological conditions. Several mechanistically distinct forms of this type of synaptic plasticity have been identified and their molecular mechanisms are starting to be unravelled. Most studies have focused on forms of LTD that are triggered by synaptic activation of either NMDARs (N-methyl-d-aspartate receptors) or metabotropic glutamate receptors (mGluRs). Converging evidence supports a crucial role of LTD in some types of learning and memory and in situations in which cognitive demands require a flexible response. In addition, LTD may underlie the cognitive effects of acute stress, the addictive potential of some drugs of abuse and the elimination of synapses in neurodegenerative diseases.

引用

页码：459 / 473

页数：15

共 192 条

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Abraham WC, 2002, J NEUROSCI, V22, P9626

[2] Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD [J].