Hydroxylation of HIF-1: Oxygen sensing at the molecular level

被引：713

作者：

Semenza, GL ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Program Vasc Cell Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD 21205 USA

来源：

PHYSIOLOGY | 2004年 / 19卷

关键词：

D O I：

10.1152/physiol.00001.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in Po-2 are transduced to effect changes in gene expression.

引用

页码：176 / 182

页数：7

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