Different Bacterial Pathogens, Different Strategies, Yet the Aim Is the Same: Evasion of Intestinal Dendritic Cell Recognition

被引：37

作者：

Bedoui, Sammy ^{[1
]}

Kupz, Andreas ^{[1
]}

Wijburg, Odilia L. ^{[1
]}

Walduck, Anna K. ^{[1
]}

Rescigno, Maria ^{[2
]}

Strugnell, Richard A. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] European Inst Oncol, Dept Expt Oncol, Milan, Italy

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 184卷 / 05期

关键词：

REGULATORY T-CELLS; HELICOBACTER-PYLORI INFECTION; TOLL-LIKE RECEPTOR-5; OUTER-PROTEIN-P; SALMONELLA-TYPHIMURIUM; YERSINIA-ENTEROCOLITICA; ANTIGEN PRESENTATION; IMMUNE-RESPONSE; RETINOIC-ACID; IN-VIVO;

D O I：

10.4049/jimmunol.0902871

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Given the central role of intestinal dendritic cells (DCs) in the regulation of gut immune responses, it is not surprising that several bacterial pathogens have evolved strategies to prevent or bypass recognition by DCs. In this article, we will review recent findings on the interaction between intestinal DCs and prototypical bacterial pathogens, such as Salmonella Yersinia or Helicobacter. We will discuss the different approaches with which these pathogens seek to evade DC recognition and subsequent T cell activation. These diverse strategies span to include mounting irrelevant immune responses, inhibition of Ag presentation by DCs, and stretch as far as to manipulate the Th1/Th2 balance of CD4(+) T cells in the bacteria's favor. The Journal of Immunology, 2010, 184: 2237-2242.

引用

页码：2237 / 2242

页数：6

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