Towards the synthesis of osteoclast inhibitor SB-242784

被引：14

作者：

Conde, JJ ^{[1
]}

McGuire, M ^{[1
]}

Wallace, M ^{[1
]}

机构：

[1] GlaxoSmithKline Pharmaceut, Dept Synthet Chem, King Of Prussia, PA 19406 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(03)00544-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Osteoclast inhibitor SB-242784 (1) was prepared from pivotal indol intermediate 4. A 'Stille' cross coupling of organotin 2c with bromo acrylate 11 afforded diene 12 which was also obtained via a reduction-isomerization process of enyne 16. Bromoamide 3 was prepared from the corresponding acid 7 which was readily obtained from bromopyruvic acid. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3081 / 3084

页数：4

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