Metalloproteinases in development and progression of vascular disease

被引:81
作者
Lijnen, HR [1 ]
机构
[1] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium
关键词
restenosis; neointima; atherosclerosis; aneurysm; metalloproteinase;
D O I
10.1159/000083814
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Remodeling of the vascular wall plays a role in many physiological processes, but also in the pathogenesis of major cardiovascular diseases such as restenosis and atherosclerosis. Remodeling requires proteolytic activity to degrade components of the extracellular matrix; this can be generated by the matrix metalloproteinase (MMP) system alone or in concert with the fibrinolytic (plasminogen/plasmin) system. Several lines of evidence suggest that the MMP system plays a role in vascular smooth muscle cell migration and neointima formation after vascular injury. In atherosclerotic lesions, active MMPs may contribute to plaque destabilisation by degrading extracellular matrix components, but may also promote aneurysm formation by proteolytic degradation of the elastic lamina. The MMP system may therefore represent a potential therapeutic target for treatment of restenosis or atherosclerosis. Copyright (C) 2004 S. Karger AG, Base.
引用
收藏
页码:275 / 281
页数:7
相关论文
共 83 条
[1]   Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model [J].
Allaire, E ;
Forough, R ;
Clowes, W ;
Starcher, B ;
Clowes, AW .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) :1413-1420
[2]   Immunolocalization of matrix metalloproteinases in rabbit carotid arteries after balloon denudation [J].
Aoyagi, M ;
Yamamoto, M ;
Azuma, H ;
Nagashima, G ;
Niimi, Y ;
Tamaki, M ;
Hirakawa, K ;
Yamamoto, K .
HISTOCHEMISTRY AND CELL BIOLOGY, 1998, 109 (02) :97-102
[3]   Prospective, randomized, double-blind trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques [J].
Axisa, B ;
Loftus, IM ;
Naylor, AR ;
Goodall, S ;
Jones, L ;
Bell, PRF ;
Thompson, MM .
STROKE, 2002, 33 (12) :2858-2864
[4]   Matrix metalloproteinases, inflammation and atherosclerosis: therapeutic perspectives [J].
Beaudeux, JL ;
Giral, P ;
Bruckert, E ;
Foglietti, MJ ;
Chapman, MJ .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2004, 42 (02) :121-131
[5]   Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 as potential markers of carotid atherosclerosis in infraclinical hyperlipidemia [J].
Beaueux, JL ;
Giral, P ;
Bruckert, E ;
Bernard, M ;
Foglietti, MJ ;
Chapman, MJ .
ATHEROSCLEROSIS, 2003, 169 (01) :139-146
[6]   SMOOTH-MUSCLE CELL-MIGRATION AND MATRIX METALLOPROTEINASE EXPRESSION AFTER ARTERIAL INJURY IN THE RAT [J].
BENDECK, MP ;
ZEMPO, N ;
CLOWES, AW ;
GALARDY, RE ;
REIDY, MA .
CIRCULATION RESEARCH, 1994, 75 (03) :539-545
[7]   Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease [J].
Blankenberg, S ;
Rupprecht, HJ ;
Poirier, O ;
Bickel, C ;
Smieja, M ;
Hafner, G ;
Meyer, J ;
Cambien, F ;
Tiret, L .
CIRCULATION, 2003, 107 (12) :1579-1585
[8]   The ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits [J].
Bocan, TMA ;
Krause, BR ;
Rosebury, WS ;
Mueller, SB ;
Lu, XK ;
Dagle, C ;
Major, T ;
Lathia, C ;
Lee, H .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (01) :70-79
[9]   ASTACINS, SERRALYSINS, SNAKE-VENOM AND MATRIX METALLOPROTEINASES EXHIBIT IDENTICAL ZINC-BINDING ENVIRONMENTS (HEXXHXXGXXH AND MET-TURN) AND TOPOLOGIES AND SHOULD BE GROUPED INTO A COMMON FAMILY, THE METZINCINS [J].
BODE, W ;
GOMISRUTH, FX ;
STOCKLER, W .
FEBS LETTERS, 1993, 331 (1-2) :134-140
[10]   Tissue inhibitors of metalloproteinases: evolution, structure and function [J].
Brew, K ;
Dinakarpandian, D ;
Nagase, H .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 2000, 1477 (1-2) :267-283