Targeting FLT3 kinase in acute myelogenous leukemia: Progress, perils, and prospects

被引：12

作者：

Heinrich, MC

机构：

[1] Oregon Hlth & Sci Univ, Div Hematol & Med Oncol, Portland, OR 97201 USA

[2] Portland VA Med Ctr, Portland, OR 97201 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 03期

关键词：

FLT3; tyrosine kinase; kinase inhibitor; AML; KIT; PDGFR;

D O I：

10.2174/1389557043487394

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Activating mutations of the FLT3 receptor tyrosine kinase are the most common recurring genetic abnormality in acute myelogenous leukemia (AM). Inhibition of FLT3 kinase activity by small molecule inhibitors has been proposed as a novel therapeutic approach AML. The pre-clinical and clinical development of candidate FLT3 inhibitors will be reviewed.

引用

收藏

页码：255 / 271

页数：17

相关论文

共 152 条

[1] Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia [J].

Abu-Duhier, FM ;

Goodeve, AC ;

Wilson, GA ;

Care, RS ;

Peake, IR ;

Reilly, JT .

BRITISH JOURNAL OF HAEMATOLOGY, 2001, 113 (04) :983-988

[2] FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group [J].

Abu-Duhier, FM ;

Goodeve, AC ;

Wilson, GA ;

Gari, MA ;

Peake, IR ;

Rees, DC ;

Vandenberghe, EA ;

Winship, PR ;

Reilly, JT .

BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (01) :190-195

[3]

Advani SH, 1999, AM J HEMATOL, V60, P87, DOI 10.1002/(SICI)1096-8652(199902)60:2<87::AID-AJH1>3.0.CO

[4]

2-5

[5] GENOMIC STRUCTURE OF THE DOWNSTREAM PART OF THE HUMAN FLT3 GENE - EXON/INTRON STRUCTURE CONSERVATION AMONG GENES ENCODING RECEPTOR TYROSINE KINASES (RTK) OF SUBCLASS-III [J].

AGNES, F ;

SHAMOON, B ;

DINA, C ;

ROSNET, O ;

BIRNBAUM, D ;

GALIBERT, F .

GENE, 1994, 145 (02) :283-288

[6]

Baldwin BR, 2001, BLOOD, V98, p156B

[7] Phase I and II clinical trials of trastuzumab [J].

Baselga, J .

ANNALS OF ONCOLOGY, 2001, 12 :49-55

[8] C-kit mutations in core binding factor leukemias [J].

Beghini, A ;

Peterlongo, P ;

Ripamonti, CB ;

Larizza, L ;

Cairoli, R ;

Morra, E ;

Mecucci, C .

BLOOD, 2000, 95 (02) :726-727

[9]

BESELGA J, 2001, ANN ONCOL S1, V12, pS35

[10] Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase [J].

Beslu, N ;

LaRose, J ;

Casteran, N ;

Birnbaum, D ;

Lecoq, E ;

Dubreuil, P ;

Rottapel, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (33) :20075-20081

← 1 2 3 4 5 6 7 8 9 10 →