A new synthesis of cytoxazone and its diastereomers provides key initial SAR information

被引：35

作者：

Carter, PH ^{[1
]}

LaPorte, JR ^{[1
]}

Scherle, PA ^{[1
]}

Decicco, CP ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(03)00131-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A short, enantioselective, and diastereoselective synthesis of cytoxazone, a Th2-selective immunomodulator from Streptomyces, is described. The route was readily adapted to the synthesis of the three other stereoisomers of natural cytoxazone. Evaluation of these compounds revealed that the stereochemical configuration of the oxazolidinone ring did not influence their biological activity. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1237 / 1239

页数：3

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