Chemical modification of nodulisporic acid A: Preliminary structure-activity relationships

被引：20

作者：

Meinke, PT

Ayer, MB

Colletti, SL

Li, CS

Lim, J

Ok, D

Salva, S

Schmatz, DM

Shih, TL

Shoop, WL

Warmke, LM

Wyvratt, MJ

Zakson-Aiken, M

Fisher, MH

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Basic Anim Sci Res, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(00)00469-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1 into 'permissive' and 'nonpermissive' regions and led to the discovery of new nodulisporamides with significantly improved flea efficacy. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2371 / 2374

页数：4

共 22 条

[1] Ion channels as targets for insecticides [J].