Novel adducts of the anticancer drug oxaliplatin with glutathione and redox reactions with glutathione disulfide

被引：61

作者：

Fakih, S ^{[1
]}

Munk, VP ^{[1
]}

Shipman, MA ^{[1
]}

Murdoch, PD ^{[1
]}

Parkinson, JA ^{[1
]}

Sadler, PJ ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2003年 / 06期

关键词：

antitumour agents; platinum; S ligands; peptides; redox chemistry;

D O I：

10.1002/ejic.200390156

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reactions of [Pt(rac-1,2-DACH)Cl-2], [Pt(1R,2R-DACH)Cl-2] and the anticancer drug oxaliplatin with the tripeptide glutathione and glutathione disulfide have been studied by HPLC, ESI-MS and NMR methods. The same two major products are formed in each reaction: a thiolate-bridged dimer and a novel thiolate-bridged dinuclear macrochelate containing a nine-membered chelate ring. Redox reactions of Pt-II anticancer drugs with biological disulfides are of potential importance to their mechanism of action. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

引用

页码：1206 / 1214

页数：9

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