Immunization with recombinant Plasmodium yoelii merozoite surface protein 4/5 protects mice against lethal challenge

被引：37

作者：

Kedzierski, L ^{[1
]}

Black, CG ^{[1
]}

Coppel, RL ^{[1
]}

机构：

[1] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 10期

关键词：

D O I：

10.1128/IAI.68.10.6034-6037.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmodium yoelii merozoite surface protein 4/5 (PyMSP4/5), expressed as a recombinant protein, was highly effective at protecting mice against lethal challenge with P. yoelii. There was a significant correlation between prechallenge antibody levels and peak parasitemia, suggesting that the homolognes of PyMSP4/5 in Plasmodlum falciparum are promising components of a subunit vaccine against malaria.

引用

收藏

页码：6034 / 6037

页数：4

相关论文

共 26 条

[1] IMMUNOGLOBULIN G(2A) ISOTYPE MAY HAVE A PROTECTIVE ROLE IN PLASMODIUM-BERGHEI NK65 INFECTION IN IMMUNIZED MICE [J].

AKANMORI, BD ;

WAKI, S ;

SUZUKI, M .

PARASITOLOGY RESEARCH, 1994, 80 (08) :638-641

[2] Immunisation with recombinant AMA-1 protects mice against infection with Plasmodium chabaudi [J].

Anders, RF ;

Crewther, PE ;

Edwards, S ;

Margetts, M ;

Matthew, MLSM ;

Pollock, B ;

Pye, D .

VACCINE, 1998, 16 (2-3) :240-247

[3]

ANDERS RF, 1993, MOL IMMUNOLOGICAL CO, P169

[4] Identification of the Plasmodium chabaudi homologue of merozoite surface proteins 4 and 5 of Plasmodium falciparum [J].

Black, CG ;

Wang, L ;

Hibbs, AR ;

Werner, E ;

Coppel, RL .

INFECTION AND IMMUNITY, 1999, 67 (05) :2075-2081

[5] Plasmodium yoelii: The role of the individual epidermal growth factor-like domains of the merozoite surface protein-1 in protection from malaria [J].

Calvo, PA ;

Daly, TM ;

Long, CA .

EXPERIMENTAL PARASITOLOGY, 1996, 82 (01) :54-64

[6] Protective immune responses to apical membrane antigen 1 of Plasmodium chabaudi involve recognition of strain-specific epitopes [J].

Crewther, PE ;

Matthew, MLSM ;

Flegg, RH ;

Anders, RF .

INFECTION AND IMMUNITY, 1996, 64 (08) :3310-3317

[7]

DALY TM, 1995, J IMMUNOL, V155, P236

[8] A RECOMBINANT 15-KILODALTON CARBOXYL-TERMINAL FRAGMENT OF PLASMODIUM-YOELII-YOELII 17XL MEROZOITE SURFACE PROTEIN-1 INDUCES A PROTECTIVE IMMUNE-RESPONSE IN MICE [J].

DALY, TM ;

LONG, CA .

INFECTION AND IMMUNITY, 1993, 61 (06) :2462-2467

[9] INVOLVEMENT OF T-CELLS IN MALARIA IMMUNITY - IMPLICATIONS FOR VACCINE DEVELOPMENT [J].

GOOD, MF ;

MILLER, LH .

VACCINE, 1989, 7 (01) :3-9

[10] Immune effector mechanisms in malaria [J].

Good, MF ;

Doolan, DL .

CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (04) :412-419