Immunological tolerance to inhaled antigen

被引:33
作者
Hoyne, GF [1 ]
Tan, K [1 ]
Corsin-Jimenez, M [1 ]
Wahl, K [1 ]
Stewart, M [1 ]
Howie, SEM [1 ]
Lamb, JR [1 ]
机构
[1] Univ Edinburgh, MRC, Ctr Inflammat Res, Immunobiol Grp, Edinburgh EH8 9AG, Midlothian, Scotland
关键词
D O I
10.1164/ajrccm.162.supplement_3.15tac6
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Regulatory mechanisms exist in the immune system to limit the induction of pathogenic responses to antigens encountered within the respiratory tract. The development of allergic disease is thought to arise as a result of the breakdown in these regulatory processes. In this review we examine the nature of immune responses generated to inhaled protein antigens and the mechanisms used to establish tolerance to inhaled antigens.
引用
收藏
页码:S169 / +
页数:7
相关论文
共 52 条
  • [1] Anderton SM, 1998, EUR J IMMUNOL, V28, P1251, DOI 10.1002/(SICI)1521-4141(199804)28:04<1251::AID-IMMU1251>3.0.CO
  • [2] 2-O
  • [3] Notch signaling: Cell fate control and signal integration in development
    Artavanis-Tsakonas, S
    Rand, MD
    Lake, RJ
    [J]. SCIENCE, 1999, 284 (5415) : 770 - 776
  • [4] NOTCH SIGNALING
    ARTAVANISTSAKONAS, S
    MATSUNO, K
    FORTINI, ME
    [J]. SCIENCE, 1995, 268 (5208) : 225 - 232
  • [5] An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    Asseman, C
    Mauze, S
    Leach, MW
    Coffman, RL
    Powrie, F
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) : 995 - 1003
  • [6] Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10
    Burkhart, C
    Liu, GY
    Anderton, SM
    Metzler, B
    Wraith, DC
    [J]. INTERNATIONAL IMMUNOLOGY, 1999, 11 (10) : 1625 - 1634
  • [7] REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS
    CHEN, YH
    KUCHROO, VK
    INOBE, J
    HAFLER, DA
    WEINER, HL
    [J]. SCIENCE, 1994, 265 (5176) : 1237 - 1240
  • [8] THE ROLE OF NOTCH IN LATERAL INHIBITION AND CELL FATE SPECIFICATION
    CHITNIS, AB
    [J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 1995, 6 (04) : 311 - 321
  • [9] Murine allergic respiratory responses to the major house dust mite allergen Der p 1
    Clarke, AH
    Thomas, WR
    Rolland, JM
    Dow, C
    O'Brien, RM
    [J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1999, 120 (02) : 126 - 134
  • [10] DICK AD, 1994, IMMUNOLOGY, V82, P625