Vitamin D receptor and growth inhibition by 1,25-dihydroxyvitamin D-3 in human malignant melanoma cell lines

被引:88
作者
Evans, SRT
Houghton, AM
Schumaker, L
Brenner, RV
Buras, RR
Davoodi, F
Nauta, RJ
Shabahang, M
机构
[1] Department of Surgery, Lombardi Cancer Center, Georgetown University Hospital, Washington
[2] Department of Surgery, 4 PHC, Georgetown University Hospital, Washington, DC 20007, 3800 Reservoir Road, N.W
关键词
D O I
10.1006/jsre.1996.0092
中图分类号
R61 [外科手术学];
学科分类号
摘要
The expression of vitamin D receptors (VDR) and growth inhibition induced by 1,25-dihydroxyvitamin D-3 have been noted in certain human malignant melanoma cell lines. In this study, widely disparate levels of VDR mRNA expression were demonstrated in a panel of eight human malignant melanoma cell lines. Quantitation of receptor level by ligand binding assay showed a similar pattern. Proliferation and growth curve analysis was performed in two cell lines: RPMI 7951 (high VDR) and SK-MEL-28 (low VDR). Significant growth inhibition was noted in RPMI 7951 cells at 10(-9) M 1,25-dihydroxyvitamin Ds SK-MEL-28 cells, which express much lower levels of VDR, did not show any growth inhibition except at extremely high concentrations of 1,25-dihydroxyvitamin D-3, namely 10(-6) M. These findings suggest a receptor-mediated mechanism of growth inhibition for 1,25-dihydroxyvitamin Ds and a role for this hormone in the growth of malignant melanoma cells. (C) 1996 Academic Press, Inc.
引用
收藏
页码:127 / 133
页数:7
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