Reaction of benzyl Grignard reagents with trifluoroacetyldihydropyrans and other cyclic β-alkoxy-α,β-unsaturated trifluoromethylketones

被引：20

作者：

Coles, SJ

Mellor, JM ^{[1
]}

El-Sagheer, AH

Salem, EEDM

Metwally, RN

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia, Egypt

[3] Suez Canal Univ, Fac Petr & Min Engn, Dept Sci & Maths, Suez, Egypt

来源：

TETRAHEDRON | 2000年 / 56卷 / 51期

关键词：

additions; Grignard reagents; trifluoromethylketones;

D O I：

10.1016/S0040-4020(00)00976-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzyl Grignard reagents react with cyclic beta -alkoxy-alpha,beta -unsaturated trifluoromethyl ketones by 1,2-addition to afford unsaturated allylic alcohols in high yield. The factors determining the balance between 1,2- and 1,4-addition to unsaturated ketones are discussed. The structures of major and minor products are established by single crystal X-ray diffraction studies. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：10057 / 10066

页数：10

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