Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness

被引:53
作者
Ferguson, MAJ [1 ]
机构
[1] Univ Dundee, Wellcome Trust Bioctr, Div Mol Parasitol & Biol Chem, Dundee DD1 5EH, Scotland
关键词
D O I
10.1073/pnas.97.20.10673
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
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页码:10673 / 10675
页数:3
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共 29 条
[1]   A STRUCTURAL MOTIF IN THE VARIANT SURFACE GLYCOPROTEINS OF TRYPANOSOMA-BRUCEI [J].
BLUM, ML ;
DOWN, JA ;
GURNETT, AM ;
CARRINGTON, M ;
TURNER, MJ ;
WILEY, DC .
NATURE, 1993, 362 (6421) :603-609
[2]  
Cross G.A.M., 1976, P413
[3]   IDENTIFICATION, PURIFICATION AND PROPERTIES OF CLONE-SPECIFIC GLYCOPROTEIN ANTIGENS CONSTITUTING SURFACE COAT OF TRYPANOSOMA-BRUCEI [J].
CROSS, GAM .
PARASITOLOGY, 1975, 71 (DEC) :393-+
[4]   Antigenic variation in trypanosomes: Secrets surface slowly [J].
Cross, GAM .
BIOESSAYS, 1996, 18 (04) :283-291
[5]  
Ferguson MAJ, 1999, J CELL SCI, V112, P2799
[6]   GLYCOSYL-PHOSPHATIDYLINOSITOL MOIETY THAT ANCHORS TRYPANOSOMA-BRUCEI VARIANT SURFACE GLYCOPROTEIN TO THE MEMBRANE [J].
FERGUSON, MAJ ;
HOMANS, SW ;
DWEK, RA ;
RADEMACHER, TW .
SCIENCE, 1988, 239 (4841) :753-759
[7]  
GUTHER MLS, 1994, J BIOL CHEM, V269, P18694
[8]   Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):: Protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins [J].
Hilley, JD ;
Zawadzki, JL ;
McConville, MJ ;
Coombs, GH ;
Mottram, JC .
MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (04) :1183-1195
[9]   Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana [J].
Ilg, T .
EMBO JOURNAL, 2000, 19 (09) :1953-1962
[10]   Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana [J].
Ilgoutz, SC ;
Zawadzki, JL ;
Ralton, JE ;
McConville, MJ .
EMBO JOURNAL, 1999, 18 (10) :2746-2755