Characterization of NKR+ T-cell subsets in human bone marrow:: implications for immunosurveillance of neoplasia

In addition to hematopoietic progenitors, human bone marrow contains mature T/NK lymphocytes. Valpha24Vbeta11 NKT-cells, a subset of NK receptor(+) (NKR+) T-cells in humans, are rare in bone marrow, suggesting the presence of other NKR+ T-cells which may contribute to tumor surveillance. NKR+/- T-cells were examined in blood (PB), and bone marrow from donors (DM) and patients with active hematopoietic malignancy (PM), or in remission (PR). T-cells in PR & PM were enriched for CD56(+) and CD57(+) subsets, compared to DM. All marrow NKR+/- T-cell subsets were more activated than PB. PM and, Surprisingly, PR marrow contained more activated cells than DM. CD8(+) cells were significantly increased in all patient marrows and there was evidence of the formation of all effector/memory pool in malignant marrow. These data suggest that NKR+ T-cell enrichment in human bone marrow that has been exposed to neoplastic transformation is compatible with a role in localized tumor surveillance/eradication. (C) 2004 Published by Elsevier Inc.