A lead-filled G-quadruplex:: Insight into the G-quartet's selectivity for Pb2+ over K+

被引：160

作者：

Kotch, FW ^{[1
]}

Fettinger, JC ^{[1
]}

Davis, JT ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 21期

关键词：

D O I：

10.1021/ol0065120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

GRAPHICS The lipophilic nucleoside, G 1, extracts Pb2+ picrate from water into organic solvents to give structures based on the hydrogen-bonded G-quartet. Crystal structures indicate important differences between (G 1)(8)-Pb2+ and (G 1)(8)-K+. The divalent Pb2+ templates a smaller G(8) cage than does K+, as judged by the M-O6 bond length, O6-O6 diagonal distance, and inter-tetramer separation. The more compact Pb2+ octamer correlates with NMR data indicating that N2-N7 hydrogen bonds in (G 1)(8)-Pb2+ are kinetically more stable than in (G I)(8)-K+.

引用

页码：3277 / 3280

页数：4

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