The discovery value of "big science"

被引:26
作者
Esparza, Jose [1 ]
Yamada, Tadataka [1 ]
机构
[1] Bill & Melinda Gates Fdn, Seattle, WA 98102 USA
关键词
D O I
10.1084/jem.20070073
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The increasing complexity of biomedical research is leading to the exploration of new models for large-scale collaborative research. This Big Science approach, however, has created anxieties and potential tensions between investigator-driven research, and research guided by a more organized, collaborative effort. Another potential tension exists between research conducted purely in search of new knowledge and research aimed at finding solutions. We argue that big biomedicine-the work of coordinated multidisciplinary groups that use the latest technologies to solve complex problems can be an important way to harness the creativity of individual investigators, stimulate innovation, and supply the infrastructure, experimental systems, and resources needed to solve the urgent health problems confronted by our global society. We discuss this using the example of the Global HIV Vaccine Enterprise.
引用
收藏
页码:701 / 704
页数:4
相关论文
共 26 条
[1]   Immunology in the post-genomic era [J].
Aderem, A ;
Hood, L .
NATURE IMMUNOLOGY, 2001, 2 (05) :373-375
[2]  
[Anonymous], 1997, Pasteur's quadrant: Basic science and technological innovation
[3]  
[Anonymous], 1964, The structure of scientific revolutions
[4]   Network theory -: The emergence of the creative enterprise [J].
Barabási, AL .
SCIENCE, 2005, 308 (5722) :639-641
[5]   Ambitious AIDS grants deepen rift between researchers [J].
Basu, Paroma .
NATURE MEDICINE, 2006, 12 (08) :865-865
[6]   AIDS vaccine research becomes 'big science' [J].
Butler, Declan .
NATURE, 2006, 442 (7103) :610-611
[7]   Immunology - New virtual center aims to speed AIDS vaccine progress [J].
Cohen, J .
SCIENCE, 2005, 309 (5734) :541-541
[8]  
Cohen J, 2006, SCIENCE, V313, P283
[9]   The human genome project: Lessons from large-scale biology [J].
Collins, FS ;
Morgan, M ;
Patrinos, A .
SCIENCE, 2003, 300 (5617) :286-290
[10]  
*COORD COMM GLOB H, 2005, PLOS MED, V2, P111