The Impact of Systemic Inflammation on Neurodevelopment

被引：257

作者：

Jiang, Nona M. ^{[1
,2
]}

Cowan, Maureen ^{[1
]}

Moonah, Shannon N. ^{[1
]}

Petri, William A., Jr. ^{[1
]}

机构：

[1] Univ Virginia, Dept Med, Div Infect Dis, MR4 Bldg Room 2115, Charlottesville, VA 22908 USA

[2] Yale Univ, Dept Med, New Haven, CT 06520 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2018年 / 24卷 / 09期

关键词：

MATERNAL IMMUNE ACTIVATION; ENVIRONMENTAL ENTEROPATHY; BRAIN-DEVELOPMENT; HIPPOCAMPAL NEUROGENESIS; DEVELOPING-COUNTRIES; EXTREMELY PRETERM; CHILD-DEVELOPMENT; MICROGLIA EMERGE; CYTOKINE LEVELS; CEREBRAL-PALSY;

D O I：

10.1016/j.molmed.2018.06.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Inflammatory mediators affect the brain during development. Neurodevelopmental disorders such as autism spectrum disorders, cognitive impairment, cerebral palsy, epilepsy, and schizophrenia have been linked to early life inflammation. Recent advances have shown the effects of systemic inflammation on childrens neurodevelopment. We discuss the potential mechanisms by which inflammatory molecules can exert their effects on the developing brain and consider the roles of MHC class I molecules, the HPA axis, glial cells, and monoamine metabolism. Methods to prevent the effects of cytokine imbalance may lead to the development of new therapeutics for neuropsychiatric disorders. Future research should focus on identifying at-risk individuals and early effective interventions to prevent long-term neurodevelopmental disabilities.

引用

页码：794 / 804

页数：11

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