Quantitation of a new potent angiotensin II receptor antagonist, TCV-116, and its metabolites in human serum and urine

被引：24

作者：

Miyabayashi, T ^{[1
]}

Okuda, T ^{[1
]}

Motohashi, M ^{[1
]}

Izawa, K ^{[1
]}

Yashiki, T ^{[1
]}

机构：

[1] TAKEDA ANALYT RES LABS LTD,YODOGAWA KU,OSAKA 532,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1996年 / 677卷 / 01期

关键词：

TCV-116; angiotensin II receptor antagonist;

D O I：

10.1016/0378-4347(95)00405-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A sensitive high-performance liquid chromatographic (HPLC) method is described for the determination of a new potent antihypertensive agent, TCV-116, and its two metabolites (M-I and M-II) in human serum or urine. After pre-treatment of the specimens, the analytes were determined using a column switching technique, except for the metabolites in urine which were determined by gradient elution mode HPLC. The quantitation limits for TCV-116, M-I and M-II were all 0.5 ng/ml in serum, and 0.5, 10 and 10 ng/ml in urine, respectively. The methods were applied to clinical trials of TCV-116.

引用

页码：123 / 132

页数：10

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