(+)-3-oxo-23,24-dinor-5α-cholan-22-oic acid:: Hydrogen-bonding patterns in a steroidal keto acid and its monohydrate

被引：31

作者：

Lalancette, RA ^{[1
]}

Thompson, HW ^{[1
]}

Brunskill, APJ ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem, Carl A Olson Mem Labs, Newark, NJ 07102 USA

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1998年 / 54卷

关键词：

D O I：

10.1107/S0108270197016296

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The X-ray crystal structures of the title steroidal keto acid in both its anhydrous, C22H34O3, (I), and monohydrate, C22H34O3.H2O, (II), forms have been determined. Neither hydrogen-bonding pattern involves the ketone. Compound (I) forms infinite carboxyl-to-carboxyl hydrogen-bonding chains. This is the first observed case of a keto carboxylic acid forming such an acid-to-acid catemer, In (II), each carboxyl is hydrogen bonded to three water molecules and each water forms hydrogen bonds with carboxyl groups from three steroid molecules, creating a network of connected ten-membered hydrogen-bonding rings.

引用

页码：421 / 424

页数：4

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