Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2

被引：254

作者：

Barford, D

Neel, BG

机构：

[1] Univ Oxford, Mol Biophys Lab, Oxford OX1 3QU, England

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Div Hematol & Oncol, Boston, MA 02215 USA

来源：

STRUCTURE | 1998年 / 6卷 / 03期

关键词：

D O I：

10.1016/S0969-2126(98)00027-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of the protein tyrosine phosphatase SHP-2 reveals the mechanism of auto-inhibition of phosphatase activity by its SH2 domains, Phosphotyrosine peptide stimulation of the phosphatase activity, resulting from peptide binding to the N-terminal SH2 domain, is linked to conformational changes within the protein, including an unprecedented allosteric transition of the N-terminal SH2 domain.

引用

页码：249 / 254

页数：6

共 33 条

[1] Allard JD, 1996, DEVELOPMENT, V122, P1137
[2] CRYSTAL-STRUCTURE OF HUMAN PROTEIN-TYROSINE-PHOSPHATASE 1B
BARFORD, D
FLINT, AJ
TONKS, NK
[J]. SCIENCE, 1994, 263 (5152) : 1397 - 1404
[3] Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization
Bilwes, AM
denHertog, J
Hunter, T
Noel, JP
[J]. NATURE, 1996, 382 (6591) : 555 - 559
[4] DECHERT U, 1994, J BIOL CHEM, V269, P5602
[5] LIGAND-MEDIATED NEGATIVE REGULATION OF A CHIMERIC TRANSMEMBRANE RECEPTOR TYROSINE PHOSPHATASE
DESAI, DM
SAP, J
SCHLESSINGER, J
WEISS, A
[J]. CELL, 1993, 73 (03) : 541 - 554
[6] Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2
Eck, MJ
Pluskey, S
Trub, T
Harrison, SC
Shoelson, SE
[J]. NATURE, 1996, 379 (6562) : 277 - 280
[7] Crystal structure of the tyrosine phosphatase SHP-2
Hof, P
Pluskey, S
Dhe-Paganon, S
Eck, MJ
Shoelson, SE
[J]. CELL, 1998, 92 (04) : 441 - 450
[8] The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu
Hoffmann, KMV
Tonks, NK
Barford, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) : 27505 - 27508
[9] STRUCTURAL BASIS FOR PHOSPHOTYROSINE PEPTIDE RECOGNITION BY PROTEIN-TYROSINE-PHOSPHATASE 1B
JIA, ZC
BARFORD, D
FLINT, AJ
TONKS, NK
[J]. SCIENCE, 1995, 268 (5218) : 1754 - 1758
[10] MOLSCRIPT - A PROGRAM TO PRODUCE BOTH DETAILED AND SCHEMATIC PLOTS OF PROTEIN STRUCTURES
KRAULIS, PJ
[J]. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1991, 24 : 946 - 950

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