Building blood vessels - stem cell models in vascular biology

被引：78

作者：

Jakobsson, Lars ^{[1
]}

Kreuger, Johan ^{[1
]}

Claesson-Welsh, Lena ^{[1
]}

机构：

[1] Uppsala Univ, Dept Genet & Pathol, S-75185 Uppsala, Sweden

来源：

JOURNAL OF CELL BIOLOGY | 2007年 / 177卷 / 05期

关键词：

D O I：

10.1083/jcb.200701146

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Spheroids of differentiating embryonic stem cells, denoted embryoid bodies, constitute a high-quality model for vascular development, particularly well suited for loss-of-function analysis of genes required for early embryogenesis. This review examines vasculogenesis and angiogenesis in murine embryoid bodies and discusses the promise of stem cell-based models for the study of human vascular development.

引用

页码：751 / 755

页数：5

共 41 条

[1] Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A [J].

Bautch, VL ;

Redick, SD ;

Scalia, A ;

Harmaty, M ;

Carmeliet, P ;

Rapoport, R .

BLOOD, 2000, 95 (06) :1979-1987

[2] beta 1 integrin is essential for teratoma growth and angiogenesis [J].

Bloch, W ;

Forsberg, E ;

Lentini, S ;

Brakebusch, C ;

Martin, K ;

Krell, HW ;

Weidle, UH ;

Addicks, K ;

Fassler, R .

JOURNAL OF CELL BIOLOGY, 1997, 139 (01) :265-278

[3] Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis [J].

Carmeliet, P ;

Lampugnani, MG ;

Moons, L ;

Breviario, F ;

Compernolle, V ;

Bono, F ;

Balconi, G ;

Spagnuolo, R ;

Oosthuyse, B ;

Dewerchin, M ;

Zanetti, A ;

Angellilo, A ;

Mattot, V ;

Nuyens, D ;

Lutgens, E ;

Clotman, F ;

de Ruiter, MC ;

Gittenberger-de Groot, A ;

Poelmann, R ;

Lupu, F ;

Herbert, JM ;

Collen, D ;

Dejana, E .

CELL, 1999, 98 (02) :147-157

[4] Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele [J].

Carmeliet, P ;

Ferreira, V ;

Breier, G ;

Pollefeyt, S ;

Kieckens, L ;

Gertsenstein, M ;

Fahrig, M ;

Vandenhoeck, A ;

Harpal, K ;

Eberhardt, C ;

Declercq, C ;

Pawling, J ;

Moons, L ;

Collen, D ;

Risau, W ;

Nagy, A .

NATURE, 1996, 380 (6573) :435-439

[5]

Choi K, 1998, DEVELOPMENT, V125, P725

[6] MURINE FGFR-1 IS REQUIRED FOR EARLY POSTIMPLANTATION GROWTH AND AXIAL ORGANIZATION [J].

DENG, CX ;

WYNSHAWBORIS, A ;

SHEN, MM ;

DAUGHERTY, C ;

ORNITZ, DM ;

LEDER, P .

GENES & DEVELOPMENT, 1994, 8 (24) :3045-3057

[7]

DOETSCHMAN TC, 1985, J EMBRYOL EXP MORPH, V87, P27

[8] CONSEQUENCES OF LACK OF BETA-1 INTEGRIN GENE-EXPRESSION IN MICE [J].

FASSLER, R ;

MEYER, M .

GENES & DEVELOPMENT, 1995, 9 (15) :1896-1908

[9] Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene [J].

Ferrara, N ;

CarverMoore, K ;

Chen, H ;

Dowd, M ;

Lu, L ;

OShea, KS ;

PowellBraxton, L ;

Hillan, KJ ;

Moore, MW .

NATURE, 1996, 380 (6573) :439-442

[10] Using a histone yellow fluorescent protein fusion for tagging and tracking endothelial cells in ES cells and mice [J].

Fraser, ST ;

Hadjantonakis, AK ;

Sahr, KE ;

Willey, S ;

Kelly, OG ;

Jones, EAV ;

Dickinson, ME ;

Baron, MH .

GENESIS, 2005, 42 (03) :162-171

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