Elevated plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 in patients with disseminated malignant melanoma

被引：121

作者：

Krasagakis, K

Thölke, D

Farthmann, B

Eberle, J

Mansmann, U

Orfanos, CE

机构：

[1] Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Dept Dermatol, D-12200 Berlin, Germany

[2] Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Inst Med Stat, D-12200 Berlin, Germany

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 77卷 / 09期

关键词：

TGF-beta isoform; plasma level; melanoma patients;

D O I：

10.1038/bjc.1998.245

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Overexpression of transforming growth factor-beta isoforms (TGF-beta 1, -beta 2, -beta 3) has been previously reported in human melanoma cell lines and tumours. The aim of the present study was to evaluate the plasma levels of TGF-beta isoforms in melanoma patients. Significantly elevated levels of TGF-beta 1 (4.2 x the controls, P = 0.0094) and of TGF-beta 2 (1.5 x the controls. P = 0.012) but not of TGF-beta 3 were measured in patients with disseminated but not locoregional melanoma. These results indicate systemic circulation of potentially immunosuppressive peptides of the TGF-beta family in end-stage melanoma patients.

引用

页码：1492 / 1494

页数：3

共 15 条

[1] ANTI-TRANSFORMING GROWTH-FACTOR (TGF)-BETA ANTIBODIES INHIBIT BREAST-CANCER CELL TUMORIGENICITY AND INCREASE MOUSE SPLEEN NATURAL-KILLER-CELL ACTIVITY - IMPLICATIONS FOR A POSSIBLE ROLE OF TUMOR-CELL HOST TGF-BETA INTERACTIONS IN HUMAN BREAST-CANCER PROGRESSION [J].