Gadolinium-Conjugated Dendrimer Nanoclusters as a Tumor-Targeted T1 Magnetic Resonance Imaging Contrast Agent

被引：163

作者：

Cheng, Zhiliang ^{[1
]}

Thorek, Daniel L. J. ^{[1
]}

Tsourkas, Andrew ^{[1
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 02期

关键词：

dendrimers; gadolinium; imaging agents; magnetic resonance imaging; tumors; SILICA NANOPARTICLES; MRI; ENHANCEMENT; RELAXIVITY;

D O I：

10.1002/anie.200905133

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemical Equation Presented" Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture). © 2010 Wiley-VCH Verlag GmbH &. Co. KCaA."

引用

页码：346 / 350

页数：5

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