Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia

被引：15

作者：

Barfield, R. C.

Hale, G. A.

Burnette, K.

Behm, F. G.

Knapp, K.

Eldridge, P.

Handgretinger, R.

机构：

[1] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

来源：

PEDIATRIC BLOOD & CANCER | 2007年 / 48卷 / 03期

关键词：

ALL relapse; infectious disease; stem cell transplantation; tumor markers;

D O I：

10.1002/pbc.20687

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 21-year-old white male with relapsed acute lymphoblastic leukemia (ALL) developed an invasive Zygomycosis infection 3 weeks after beginning re-induction chemotherapy. Because of the high risk of fatal recurrence of the fungal infection, neither long-term maintenance chemotherapy nor allogeneic hematopoietic stern cell transplant (HSCT) was considered appropriate. Because his ALL blasts expressed CD34 but lacked CD133, he received a CD133 selected autologous graft following high-dose consolidation chemotherapy. The patient survives in remission 19 months after HSCT.

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收藏

页码：349 / 353

页数：5

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