Histamine H3-receptor isoforms

被引：38

作者：

Bakker, RA ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Med Chem, Leiden Amsterdam Ctr Drug Res, NL-1081 HV Amsterdam, Netherlands

来源：

INFLAMMATION RESEARCH | 2004年 / 53卷 / 10期

关键词：

histamine H-3 receptors; neurotransmitter; brain expression of H-3-R; CNS functions;

D O I：

10.1007/s00011-004-1286-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H-3 receptor allowed for the subsequent cloning of a variety of H-3 receptor isoforms from different species as well as the H-4 receptor. As a result a wide variety of H-3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H-3 receptor as a target for the development of potential therapeutics.

引用

收藏

页码：509 / 516

页数：8

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