The canine as a model of human cognitive aging: Recent developments

被引：124

作者：

Adams, B

Chan, A

Callahan, H

Milgram, NW

机构：

[1] Univ Toronto, Div Life Sci, Scarborough, ON M1C 1A4, Canada

[2] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada

[3] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada

[4] Univ Toronto, Dept Physiol, Toronto, ON, Canada

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2000年 / 24卷 / 05期

关键词：

aging; canine; cognition; learning; memory; spatial;

D O I：

10.1016/S0278-5846(00)00101-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Aged dogs display many of the cognitive impairments associated with aging and dementia. 2. Aged dogs, like humans, display a wide range of individual variability in cognitive functioning (i.e., different cognitive functions decline at different rates in aged dogs). 3. Different categories of aged canines can be identified on the basis of neuropsychological test performance,and these categories can be used to model different subgroups of aged humans (i.e., dementia, mild cognitive impairment and successful aging). 4. Additional research is required to further validate the dog as a model of human cognitive aging and dementia.

引用

页码：675 / 692

页数：18

共 52 条

[1]

ADAMS B, 1999, IN PRESS BEH BRAIN R

[2]

Almkvist O, 1998, J NEURAL TRANSM-SUPP, P21

[3]

ALMKVIST O, 1996, ACTA NEUROL SCAND S, V165, P165

[4] AGED MONKEYS EXHIBIT BEHAVIORAL DEFICITS INDICATIVE OF WIDESPREAD CEREBRAL-DYSFUNCTION [J].