Does influenza vaccination exacerbate asthma in children?

被引：21

作者：

Bueving, HJ

Bernsen, RMD

de Jongste, JC

van Suijlekom-Smit, LWA

Rimmelzwaan, GF

Osterhaus, ADME

Mölken, MPMHRV

Thomas, S

van der Wouden, JC

机构：

[1] Erasmus MC Univ, Ctr Med, Dept Gen Practice, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus MC Univ, Ctr Med, Dept Pediat, Subdiv Paediat Resp Med, NL-3000 DR Rotterdam, Netherlands

[3] Erasmus MC Univ, Ctr Med, Dept Virol, NL-3000 DR Rotterdam, Netherlands

[4] Erasmus MC Univ, Ctr Med, Inst Med Technol Assessment, NL-3000 DR Rotterdam, Netherlands

来源：

VACCINE | 2004年 / 23卷 / 01期

关键词：

influenza vaccine; adverse reactions; asthma;

D O I：

10.1016/j.vaccine.2004.03.067

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: The risks of influenza vaccination in asthmatic children are still being discussed. Especially, the risk that influenza vaccination may exacerbate asthma is an issue in this debate. Methods: We conducted a randomised double-blind placebo-controlled trial in 696 children 6-18 years of age with asthma recruited in general practice during two influenza seasons, 1999-2000 and 2000-2001. Children participated for only one season. During the first week after vaccination. participants recorded local, influenza like and asthma symptoms as well as use of medication, health care use and absenteeism. Results: Except for cough during the day in the first season, favouring placebo, there were no differences indicating that vaccination exacerbates asthma. Conclusions: Influenza vaccination does not seem to exacerbate asthma. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：91 / 96

页数：6

共 18 条

[1] Influenza vaccination in children with asthma -: Randomized double-blind placebo-controlled trial [J].