Tissue repair with a therapeutic transcription factor

被引：59

作者：

Bryant, M ^{[1
]}

Drew, GM ^{[1
]}

Houston, P ^{[1
]}

Hissey, P ^{[1
]}

Campbell, CJ ^{[1
]}

Braddock, M ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Vasc Dis Unit,Endothelial Gene Express Grp, Wound Healing & Tissue Regenerat Program, Stevenage SG1 2NY, Herts, England

来源：

HUMAN GENE THERAPY | 2000年 / 11卷 / 15期

关键词：

D O I：

10.1089/104303400750001444

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The healing of tissue involves a wide range of molecular, cellular, and physiological events that are coordinated in a temporally specific manner. The cellular transcription factor early growth response factor 1 (Egr-1) is expressed minutes after acute injury and serves to stimulate the production of a class of growth factors whose role is to promote tissue repair. We have studied the effects of Egr-1 expression at the site of dermal wounding in rodents. We find that Egr-1 promotes angiogenesis in vitro and in vivo, increases collagen production, and accelerates wound closure. These results show that Egr-1 gene therapy accelerates the normal healing process and raises the potential use of this therapeutic transcription factor for any aspect of tissue repair.

引用

页码：2143 / 2158

页数：16

共 59 条

[1] MECHANICAL STRETCH/RELAXATION OF CULTURED RAT MESANGIAL CELLS INDUCES PROTOONCOGENES AND CYCLOOXYGENASE [J].