Two iron-regulated putative ferric siderophore receptor genes in Bordetella bronchiseptica and Bordetella pertussis

被引：16

作者：

Beall, B ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Res Dis Lab Sect, Atlanta, GA 30333 USA

来源：

RESEARCH IN MICROBIOLOGY | 1998年 / 149卷 / 03期

关键词：

Bordetella bronchiseptica; iron; bfrB gene; bfrC gene; Fur-repressed genes; TonB-dependent receptors; TnphoA mutagenesis; regulation;

D O I：

10.1016/S0923-2508(98)80079-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two iron-regulated genes with deduced homology to TonB-dependent ferric siderophore receptors were cloned from Bordetella bronchiseptica by screening a library of TnphoA insertion mutants. bfrB and bfrC were iron-repressed in B. bronchiseptica by a Fur-dependent mechanism, and were expressed from promoters overlapped by potential Fur-binding sites. Both genes were highly conserved among Bordetella species and were also iron-regulated in Bordetella pertussis. bfrB and bfrC mutants of both species and a bfrB-bfrC double mutant of B. bronchiseptica had no discernible defects in utilization of known iron sources for Bordetella.

引用

页码：189 / 201

页数：13

共 32 条

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