Proteins sharing PNPLA domain, a new family of enzymes regulating lipid metabolism

被引：17

作者：

Baulande, Sylvain ^{[1
]}

Langlois, Clotilde ^{[2
]}

机构：

[1] PartnerChip CEA, F-91000 Evry, France

[2] Lab PiLeJe, F-75015 Paris, France

来源：

M S-MEDECINE SCIENCES | 2010年 / 26卷 / 02期

关键词：

ADIPOSE TRIGLYCERIDE LIPASE; NEUROPATHY TARGET ESTERASE; CALCIUM-INDEPENDENT PHOSPHOLIPASE-A(2)GAMMA; ACYL HYDROLASE; ADIPONUTRIN GENE; BETA-CELLS; PATATIN; A(2); EXPRESSION; INSULIN;

D O I：

10.1051/medsci/2010262177

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Proteins sharing PNPLA domain, a new family of enzymes regulating lipid metabolism Genome sequencing technologies led to tremendous breakthrough in biology uncovering numerous genes unknown so for and thus opening the field of deep investigations to understand their associated biological functions As a matter of fact, functional genomics have been progressively replacing sequence genomics with as a main objective to yield insight into cellular physiology Recently, an emerging group of genes coding for proteins bearing a common domain termed potatin (PNPLA domain) have been discovered Members of this new enzymatic family displaying lipase and transacylase properties appeared to hove major roles in the regulation of lipid metabolism. The aim of this review is to make an overview on the latest discoveries concerning this new family of proteins and their relationship with lipid metabolism, physiology of mammals and their potential involvement in human pathology

引用

收藏

页码：177 / 184

页数：8

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