Optimization of systemic nasal drug delivery with pharmaceutical excipients

被引：80

作者：

Behl, CR ^{[1
]}

Pimplaskar, HK ^{[1
]}

Sileno, AP ^{[1
]}

Xia, WJ ^{[1
]}

Gries, WJ ^{[1
]}

deMeireles, JC ^{[1
]}

Romeo, VD ^{[1
]}

机构：

[1] Nastech Pharmaceut Co Inc, Hauppauge, NY 11788 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1998年 / 29卷 / 1-2期

关键词：

nasal delivery; physical chemical properties; absorption factors; intranasal drug delivery; nasal solutions; nasal gels; nasal powders; absorption enhancers; absorption optimizers; bile salts;

D O I：

10.1016/S0169-409X(97)00064-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The nasal drug route provides a viable alternative for many drugs which are presently administered via parenteral and oral routes. Nasal drug absorption is optimized by improving on formulation excipients, designing various types of novel nasal dosage forms, and understanding the mechanisms of nasal drug absorption.

引用

页码：117 / 133

页数：17

共 146 条

[1] BIOAVAILABILITY OF LEUPROLIDE ACETATE FOLLOWING NASAL AND INHALATION DELIVERY TO RATS AND HEALTHY HUMANS
ADJEI, A
SUNDBERG, D
MILLER, J
CHUN, A
[J]. PHARMACEUTICAL RESEARCH, 1992, 9 (02) : 244 - 249
[2] EPITHELIAL TRANSPORT AND BIOAVAILABILITY OF INTRANASALLY ADMINISTERED HUMAN GROWTH-HORMONE FORMULATED WITH THE ABSORPTION ENHANCERS DIDECANOYL-L-ALPHA-PHOSPHATIDYLCHOLINE AND ALPHA-CYCLODEXTRIN IN RABBITS
AGERHOLM, C
BASTHOLM, L
JOHANSEN, PB
NIELSEN, MH
ELLING, F
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 83 (12) : 1706 - 1711
[3] *AM MAIZ PROD CO, 1995, CYCL COMPL GEN INF
[4] [Anonymous], ACTA PHARM TECH
[5] [Anonymous], 1998, CHEM REV
[6] ACTIVATION OF SYSTEMIC AND MUCOSAL IMMUNE-RESPONSE FOLLOWING NASAL ADMINISTRATION OF LIPOSOMES
ARAMAKI, Y
FUJII, Y
YACHI, K
KIKUCHI, H
TSUCHIYA, S
[J]. VACCINE, 1994, 12 (13) : 1241 - 1245
[7] ARIMA H, 1990, 5TH INT S CYCL, P487
[8] ARNOLD TH, 1985, THESIS U GEORGIA ATH
[9] AUNGST BJ, 1988, J PHARMACOL EXP THER, V244, P23
[10] NASAL ABSORPTION OF INTERFERON - ENHANCEMENT BY SURFACTANT AGENTS
BAGLIONI, C
PHIPPS, RJ
[J]. JOURNAL OF INTERFERON RESEARCH, 1990, 10 (05): : 497 - 504

← 1 2 3 4 5 6 7 8 9 10 →