Polyunsaturated fatty acids and their metabolites in brain function and disease

被引：1086

作者：

Bazinet, Richard P. ^{[1
]}

Laye, Sophie ^{[2
,3
]}

机构：

[1] Univ Toronto, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada

[2] INRA, UMR 1286, F-33076 Bordeaux, France

[3] Univ Bordeaux, UMR 1286, F-33076 Bordeaux, France

来源：

NATURE REVIEWS NEUROSCIENCE | 2014年 / 15卷 / 12期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

POSTMORTEM ORBITOFRONTAL CORTEX; DIETARY DOCOSAHEXAENOIC ACID; ALPHA-LINOLENIC ACID; LONG-CHAIN OMEGA-3-FATTY-ACIDS; ACYL-COA SYNTHETASES; SPINAL-CORD-INJURY; ARACHIDONIC-ACID; ALZHEIMERS-DISEASE; EICOSAPENTAENOIC ACID; PREFRONTAL CORTEX;

D O I：

10.1038/nrn3820

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids (PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the phospholipid cell membrane. Once PUFAs are released from the membrane, they can participate in signal transduction, either directly or after enzymatic conversion to a variety of bioactive derivatives ('mediators'). PUFAs and their mediators regulate several processes within the brain, such as neurotransmission, cell survival and neuroinflammation, and thereby mood and cognition. PUFA levels and the signalling pathways that they regulate are altered in various neurological disorders, including Alzheimer's disease and major depression. Diet and drugs targeting PUFAs may lead to novel therapeutic approaches for the prevention and treatment of brain disorders.

引用

页码：771 / 785

页数：15

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