DNA adduction and mutagenic properties of acrylamide

被引:71
作者
Besaratinia, A [1 ]
Pfeifer, GP [1 ]
机构
[1] City Hope Natl Med Ctr, Beckman Res Inst, Dept Biol, Duarte, CA 91010 USA
关键词
acrylamide; cII transgene; DNA adducts; glycidamide; mutations; p53; gene;
D O I
10.1016/j.mrgentox.2004.10.011
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
This review article summarizes our current knowledge on DNA damaging and mutagenic properties of acrylamide. Direct and indirect modes of interaction of acrylamide with DNA are discussed, and the resulting alkylating DNA adducts are highlighted. Emphasis is placed on glycidamide-DNA adducts generated via epoxidation of acrylamide presumably by cytochrome P4502E1. Dosimetry and mapping of acrylamide-induced DNA adducts in vitro and/or in vivo are described. Mutagenic potency and specificity of acrylamide in relation to its respective DNA adducts are discussed. Prospective views are provided on the potential applications of acrylamide-induced DNA adduct dosimetry/mapping and mutation frequency/spectrometry for biomonitoring purposes. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:31 / 40
页数:10
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