Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia

被引：48

作者：

Tanimukai, H

Imaizumi, K

Kudo, T

Katayama, T

Tsuda, M

Takagi, T

Tohyama, M

Takeda, M

机构：

[1] Osaka Univ, Sch Med, Dept Neuropsychiat, Suita, Osaka 565, Japan

[2] Osaka Univ, Sch Med, Dept Mol Neurobiol, Suita, Osaka 565, Japan

[3] Tanabe Seiyaku Co Ltd, Osaka 532, Japan

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 54卷 / 02期

关键词：

presenilin-1; Alzheimer's disease; brain ischemia; in situ hybridization;

D O I：

10.1016/S0169-328X(97)00337-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the biological roles of the presenilin-1 (PS-1) gene after neuronal injury, the changes of PS-1 mRNA expression in the gerbil hippocampus after transient ischemia were examined. From 1 day to 3 day-reperfusion after 5 min-ischemia, PS-1 mRNA was induced in the hippocampus compared with the sham-operated control. The cells which induced the PS-1 genes were neurons of CA3 and dentate gyrus, the region relatively resistant to ischemic stress. These findings suggest that the induction of PS-1 genes may be associated with some responses of neurons damaged by transient ischemia. (C) 1998 Elsevier Science B.V.

引用

收藏

页码：212 / 218

页数：7

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