Integrins: Regulators of tissue function and cancer progression

被引：92

作者：

Danen, EHJ ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Cell Biol, Amsterdam, Netherlands

来源：

CURRENT PHARMACEUTICAL DESIGN | 2005年 / 11卷 / 07期

关键词：

D O I：

10.2174/1381612053381756

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Integrins are adhesion receptors that connect cells to components of the extracellular matrix or to counter receptors on other cells. Besides mediating stable adhesion, these receptors are implicated in the deposition of extracellular matrices and they are crucial for cell migration. Integrin-mediated adhesion also modulates signal transduction cascades downstream of other receptors and thereby regulates cell Survival, proliferation, and the expression of differentiation-related genes. In this review, an overview of the evidence for roles of integrins ill tissue development and function is given and the contribution of changes in integrin expression to cancer is discussed.

引用

页码：881 / 891

页数：11

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