The ratio of dihomo-γ-linolenic acid to deoxycholic acid species is a potential biomarker for the metabolic abnormalities in obesity

被引：9

作者：

Lei, Sha ^{[1
,2
]}

Huang, Fengjie ^{[1
,2
]}

Zhao, Aihua ^{[1
,2
]}

Chen, Tianlu ^{[1
,2
]}

Chen, Wenlian ^{[7
]}

Xie, Guoxiang ^{[7
]}

Zheng, Xiaojiao ^{[1
,2
]}

Zhang, Yunjing ^{[1
,2
]}

Yu, Haoyong ^{[3
,4
,5
]}

Zhang, Pin ^{[6
]}

Rajani, Cynthia ^{[7
]}

Bao, Yuqian ^{[3
,4
,5
]}

Jia, Weiping ^{[1
,2
,3
,4
,5
]}

Jia, Wei ^{[1
,2
,7
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Lab Diabet Mellitus, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Ctr Translat Med, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol & Metab, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Diabet Inst, Shanghai Clin Ctr Diabet, Shanghai, Peoples R China

[5] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Clin Ctr Metab Dis, Shanghai, Peoples R China

[6] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Gen Surg, Shanghai, Peoples R China

[7] Univ Hawaii, Ctr Canc, 701 Ilalo St, Honolulu, HI 96813 USA

来源：

FASEB JOURNAL | 2017年 / 31卷 / 09期

关键词：

bile acid; free fatty acid; targeted metabolomics; type; 2; diabetes; Y GASTRIC BYPASS; POLYUNSATURATED FATTY-ACIDS; SERUM BILE-ACIDS; GROWTH-FACTOR; 19; BODY-MASS INDEX; GLUCOSE-METABOLISM; DIABETES REMISSION; ENERGY-EXPENDITURE; BARIATRIC SURGERY; FOOD-INTAKE;

D O I：

10.1096/fj.201700055R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Bile acid (BA) signaling regulates fatty acid metabolism. BA dysregulation plays an important role in the development of metabolic disease. However, BAs in relation to fatty acids have not been fully investigated in obesity-related metabolic disorders. A targeted metabolomic measurement of serum BA and free fatty acid profiles was applied to sera of 381 individuals in 2 independent studies. The results showed that the ratio of dihomo-gamma-linolenic acid (DGLA) to deoxycholic acid (DCA) species (DCAS) was significantly increased in obese individuals with type 2 diabetes (T2DM) from a case-control study and decreased in the remission group of obese subjects with T2DM after metabolic surgery. The changes were closely associated with their metabolic status. These results were consistently confirmed in both serum and liver of mice with diet-induced obesity, implying that such a metabolic alteration in circulation reflects changes occurring in the liver. In vitro studies of human liver L-02 cell lines under BA treatment revealed that DCA and its conjugated form, TDCA, significantly inhibited mRNA expression of fatty acid transport protein 5 in the presence of DGLA, which was involved in hepatocyte DGLA uptake. Thus, the DGLA: DCAS ratio may be a promising biomarker for metabolic abnormalities in obesity.

引用

页码：3904 / 3912

页数：9

共 48 条

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