A new facile method for the synthesis of 1-arylimidazole-5-carboxylates

被引：190

作者：

Chen, BC ^{[1
]}

Bednarz, MS ^{[1
]}

Zhao, RL ^{[1
]}

Sundeen, JE ^{[1
]}

Chen, P ^{[1
]}

Shen, ZQ ^{[1
]}

Skoumbourdis, AP ^{[1
]}

Barrish, JC ^{[1
]}

机构：

[1] Bristol Myers Squibb Pharmaceut Res Inst, Princeton, NJ 08543 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)00910-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new facile method for the preparation of 1-arylimidazole-5-carboxylates was developed. The new method involved reaction of anilines and ethyl glyoxylate in methanol to give alpha-anilino-alpha-methoxyacetates followed by cyclization with TosMIC, affording 1-arylimidazole-5-carboxylates in two steps in 40-94% overall yields. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5453 / 5456

页数：4

共 17 条

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