Antitumor vaccination using peptide based vaccines

被引：21

作者：

Eisenbach, L ^{[1
]}

Bar-Haim, E ^{[1
]}

El-Shami, K ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

IMMUNOLOGY LETTERS | 2000年 / 74卷 / 01期

关键词：

TAA; peptides; CTL; immunotherapy; vaccines;

D O I：

10.1016/S0165-2478(00)00245-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic T Lymphocytes (CTLs) recognize Major Histocompatibility Complex (MHC) class I in complex with peptides. Peptides derived from Tumor Associated Antigens (TAAs) are therefore targets for tumor rejection. A number of TAAs were identified in the last decade from human and murine tumors. Here we summarize the methods for TAA and peptide identification, the nature of TAA peptides and the making of antitumor vaccines. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：27 / 34

页数：8

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