Wnt signaling in polycystic kidney disease

被引:86
作者
Benzing, Thomas
Simons, Matias
Walz, Gerd
机构
[1] Univ Hosp Freiburg, Div Renal, D-79106 Freiburg, Germany
[2] Mt Sinai Sch Med, Dept Mol Cell & Dev Biol, New York, NY USA
来源
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2007年 / 18卷 / 05期
关键词
D O I
10.1681/ASN.2006121355
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Wnt signaling cascades activate morphogenetic programs that range from cell migration and proliferation to cell fate determination and stem cell renewal. These pathways enable cells to translate environmental cues into the complex cellular programs that are needed to organize tissues and build organs. Wnt signaling is essential for renal development; however, the specific molecular underpinnings involved are poorly understood. Recent research has revealed an unexpected intersection between Wnt signaling and polycystic kidney disease. Some polycystic kidney disease proteins, such as Inversin and Bardet-Biedl syndrome family members, were found to use components of the Wnt signaling cascade to orient cells along a secondary polarity axis within the plane of the epithelium. These spatial cues may be needed to position nascent tubules with a defined geometry.
引用
收藏
页码:1389 / 1398
页数:10
相关论文
共 88 条
[1]   THE SUBCELLULAR ORGANIZATION OF MADIN-DARBY CANINE KIDNEY-CELLS DURING THE FORMATION OF A POLARIZED EPITHELIUM [J].
BACALLAO, R ;
ANTONY, C ;
DOTTI, C ;
KARSENTI, E ;
STELZER, EHK ;
SIMONS, K .
JOURNAL OF CELL BIOLOGY, 1989, 109 (06) :2817-2832
[2]   The ciliopathies: An emerging class of human genetic disorders [J].
Badano, Jose L. ;
Mitsuma, Norimasa ;
Beales, Phil L. ;
Katsanis, Nicholas .
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2006, 7 :125-148
[3]   Life without centrioles: Cilia in the spotlight [J].
Badano, Jose L. ;
Katsanis, Nicholas .
CELL, 2006, 125 (07) :1228-1230
[4]   The orientation of cell divisions determines the shape of Drosophila organs [J].
Baena-López, LA ;
Baonza, A ;
García-Bellido, A .
CURRENT BIOLOGY, 2005, 15 (18) :1640-1644
[5]   Flies without centrioles [J].
Basto, Renata ;
Lau, Joyce ;
Vinogradova, Tatiana ;
Gardiol, Alejandra ;
Woods, C. Geoffrey ;
Khodjakov, Alexey ;
Raff, Jordan W. .
CELL, 2006, 125 (07) :1375-1386
[6]   Nephrocystin interacts with Pyk2, p130Cas, and tensin and triggers phosphorylation of Pyk2 [J].
Benzing, T ;
Gerke, P ;
Höpker, K ;
Hildebrandt, F ;
Kim, E ;
Walz, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) :9784-9789
[7]   Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport [J].
Blacque, O. E. ;
Leroux, M. R. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (18) :2145-2161
[8]   Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila [J].
Cabernard, C ;
Affolter, M .
DEVELOPMENTAL CELL, 2005, 9 (06) :831-842
[9]   Wnt signaling: complexity at the surface [J].
Cadigan, KM ;
Liu, YI .
JOURNAL OF CELL SCIENCE, 2006, 119 (03) :395-402
[10]   Phosphorylation of Pax2 by the c-jun N-terminal kinase and enhanced Pax2-dependent transcription activation [J].
Cai, Y ;
Lechner, MS ;
Nihalani, D ;
Prindle, MJ ;
Holzman, LB ;
Dressler, GR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (02) :1217-1222