Scleroglucan/borax: characterization of a novel hydrogel system suitable for drug delivery

被引:49
作者
Coviello, T
Grassi, M
Lapasin, R
Marino, A
Alhaique, F
机构
[1] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy
[2] Univ Trieste, Dipartimento Ingn Chim, I-34127 Trieste, Italy
关键词
scleroglucan; borax; hydrogel; modified release; physically crosslinked gels;
D O I
10.1016/S0142-9612(03)00087-5
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A new hydrogel, with scleroglucan using borax as a crosslinker, has been prepared. The physical gel has been loaded with a model molecule (theophylline) and the release of the drug from the gel was evaluated. The same system was used to prepare tablets and the delivery of theophylline in different environmental conditions (HCl and SIF) was determined. A recent theoretical approach has been applied to the dissolution profiles obtained from the tablets and a satisfactory agreement has been found with the experimental data. Furthermore, the diffusion coefficient of the model molecule was evaluated according to a suitable strategy that was tested on two set of data obtained with different set-ups (permeation and diffusion experiments). A simplified mathematical approach allows to reduce the two-dimensional problem of the Fick's second law in a one-dimensional system leading to a much easier handling of the data without loosing the accuracy of the original problem in two dimensions. The characterization of the gel has been also carried out following the kinetics of swelling in terms of water uptake. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2789 / 2798
页数:10
相关论文
共 38 条
[1]  
ALHAIQUE F, 1993, PHARMAZIE, V48, P432
[2]  
Alhaique F, 1990, Drug Des Deliv, V5, P249
[3]   A POSSIBLE PH-CONTROLLED DRUG DELIVERY SYSTEM BASED ON A DERIVATIVE OF THE POLYSACCHARIDE SCLEROGLUCAN [J].
ALHAIQUE, F ;
RICCIERI, FM ;
SANTUCCI, E ;
CRESCENZI, V ;
GAMINI, A .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1985, 37 (05) :310-313
[4]  
ALHAIQUE F, 1993, ACTA TECHNOL LEGIS M, V4, P21
[5]  
ALHAIQUE F, 1990, ACTA TECHNOL LEGIS M, V1, P1
[6]  
ALHAIQUE F, 2001, ACTA TECHNOL LEGIS M, V12, P185
[7]   MECHANICAL-PROPERTIES OF BORATE CROSSLINKED POLYVINYL-ALCOHOL) GELS [J].
CHENG, ATY ;
RODRIGUEZ, F .
JOURNAL OF APPLIED POLYMER SCIENCE, 1981, 26 (11) :3895-3908
[8]   A novel co-crosslinked polysaccharide: studies for a controlled delivery matrix [J].
Coviello, T ;
Dentini, M ;
Rambone, G ;
Desideri, P ;
Carafa, M ;
Murtas, E ;
Riccieri, FM ;
Alhaique, F .
JOURNAL OF CONTROLLED RELEASE, 1998, 55 (01) :57-66
[9]   Conformational characteristics of oxidized scleroglucan [J].
Coviello, T ;
Maeda, H ;
Yuguchi, Y ;
Urakawa, H ;
Kajiwara, A ;
Dentini, M ;
Crescenzi, V .
MACROMOLECULES, 1998, 31 (05) :1602-1607
[10]   A crosslinked system from Scleroglucan derivative: preparation and characterization [J].
Coviello, T ;
Grassi, M ;
Rambone, G ;
Alhaique, F .
BIOMATERIALS, 2001, 22 (13) :1899-1909