Drug-eluting stents for diabetes mellitus - A rush to judgment?

被引：36

作者：

Finn, AV

Palaclos, IF

Kastrati, A

Gold, HK

机构：

[1] Massachusetts Gen Hosp, Cardiac Unit, Boston, MA 02114 USA

[2] Tech Univ Munich, Med Klin Rechts Der Isar 1, Munich, Germany

[3] Tech Univ Munich, Deutsch Herzzentrum, Munich, Germany

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2005年 / 45卷 / 04期

关键词：

D O I：

10.1016/j.jacc.2004.10.060

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The two pivotal U.S. trials of drug-eluting stents do not establish the principle that these stents are superior to thin-strut bare-metal stents for preventing repeat revascularization in patients with diabetes. Neither study was adequately powered to make this determination. Moreover, both studies used thick-strut stents known to have high restenosis rates as controls. Low angiographic follow-up underestimates the true target lesion revascularization rate in the Polymer-Based Paclitaxel-Eluting Stent in Patients with Coronary Artery Disease (TAXUS-IV) trial because of the high incidence of silent ischemia in patients with diabetes. Optimal therapy for diabetic coronary disease should include a comprehensive approach directed toward metabolic normalization in addition to local stent-based therapy. (C) 2005 by the American College of Cardiology Foundation.

引用

收藏

页码：479 / 483

页数：5

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